Here are some cheats and tips for the game MLBPA Sports Talk Baseball.
Easy outs:
If a CPU player is on first base, throw the ball around the
bases. Eventually, the runner will attempt to steal second base
and may be thrown out.
If there are CPU players are on second and third bases or if the
bases are full, press B to throw the ball to third base.
Then, immediately throw the ball to first base. The CPU runners
will try to advance. Throw the ball to second base to get an
easy out.